Dual Role For A MEK Inhibitor As A Modulator Of Inflammation And Host Defense Mechanisms With Potential Therapeutic Application In COPD

BACKGROUND: Unlike p38 mitogen-activated protein Kinases (MAPK) that has been extensively studied in the context of lung-associated pathologies in COPD, the role of the dual-specificity mitogen-activated protein kinase kinase (MEK1/2) or its downstream signaling molecule extracellular signal-regulat...

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Detalhes bibliográficos
Publicado no:Int J Chron Obstruct Pulmon Dis
Main Authors: Kurian, Nisha, Cohen, Taylor S, Öberg, Lisa, De Zan, Erica, Skogberg, Gabriel, Vollmer, Stefan, Baturcam, Engin, Svanberg, Petter, Bonn, Britta, Smith, Paul D, Vaarala, Outi, Cunoosamy, Danen M
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6885002/
https://ncbi.nlm.nih.gov/pubmed/32063702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/COPD.S211619
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