MEK inhibition drives anti-viral defence in RV but not RSV challenged human airway epithelial cells through AKT/p70S6K/4E-BP1 signalling

BACKGROUND: The airway epithelium is a major target tissue in respiratory infections, and its antiviral response is mainly orchestrated by the interferon regulatory factor-3 (IRF3), which subsequently induces type I (β) and III (λ) interferon (IFN) signalling. Dual specificity mitogen-activated prot...

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Udgivet i:Cell Commun Signal
Main Authors: Baturcam, Engin, Vollmer, Stefan, Schlüter, Holger, Maciewicz, Rose A., Kurian, Nisha, Vaarala, Outi, Ludwig, Stephan, Cunoosamy, Danen Mootoosamy
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6639958/
https://ncbi.nlm.nih.gov/pubmed/31319869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0378-7
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