MEK inhibition drives anti-viral defence in RV but not RSV challenged human airway epithelial cells through AKT/p70S6K/4E-BP1 signalling

BACKGROUND: The airway epithelium is a major target tissue in respiratory infections, and its antiviral response is mainly orchestrated by the interferon regulatory factor-3 (IRF3), which subsequently induces type I (β) and III (λ) interferon (IFN) signalling. Dual specificity mitogen-activated prot...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Cell Commun Signal
Hlavní autoři: Baturcam, Engin, Vollmer, Stefan, Schlüter, Holger, Maciewicz, Rose A., Kurian, Nisha, Vaarala, Outi, Ludwig, Stephan, Cunoosamy, Danen Mootoosamy
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6639958/
https://ncbi.nlm.nih.gov/pubmed/31319869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0378-7
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky