The role of ubiquitin ligase E3A in polarized contact guidance and rescue strategies in UBE3A-deficient hippocampal neurons

BACKGROUND: Although neuronal extracellular sensing is emerging as crucial for brain wiring and therefore plasticity, little is known about these processes in neurodevelopmental disorders. Ubiquitin protein ligase E3A (UBE3A) plays a key role in neurodevelopment. Lack of UBE3A leads to Angelman synd...

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Publicat a:Mol Autism
Autors principals: Tonazzini, Ilaria, Van Woerden, Geeske M., Masciullo, Cecilia, Mientjes, Edwin J., Elgersma, Ype, Cecchini, Marco
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6884852/
https://ncbi.nlm.nih.gov/pubmed/31798818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-019-0293-1
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