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Evolution of a Reverse Transcriptase to Map N(1)-Methyladenosine in Human mRNA
Chemical modifications on messenger RNA are increasingly recognized as a critical regulatory layer in the flow of genetic information, but quantitative tools to monitor RNA modifications in a whole-transcriptome and site-specific manner are lacking. Here we describe a versatile directed evolution pl...
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| Publicat a: | Nat Methods |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6884687/ https://ncbi.nlm.nih.gov/pubmed/31548705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-019-0550-4 |
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