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Transcription elongation factor AFF2/FMR2 regulates expression of expanded GGGGCC repeat-containing C9ORF72 allele in ALS/FTD
Expanded GGGGCC (G(4)C(2)) repeats in C9ORF72 cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). How RNAs containing expanded G(4)C(2) repeats are transcribed in human neurons is largely unknown. Here we describe a Drosophila model in which poly(GR) expression in adult neur...
Enregistré dans:
| Publié dans: | Nat Commun |
|---|---|
| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6884579/ https://ncbi.nlm.nih.gov/pubmed/31784536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13477-8 |
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