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Insights into C9ORF72-Related ALS/FTD from Drosophila and iPSC Models
GGGGCC (G(4)C(2)) repeat expansion in C9ORF72 is the most common genetic cause of ALS and FTD. An important issue is how repeat RNAs and their translation products—various dipeptide repeat (DPR) proteins—cause neurodegeneration. Drosophila has been widely used to model G(4)C(2) repeat RNA and DPR pr...
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| Publicado no: | Trends Neurosci |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6015541/ https://ncbi.nlm.nih.gov/pubmed/29729808 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tins.2018.04.002 |
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