Suppression of FOXM1 activities and breast cancer growth in vitro and in vivo by a new class of compounds

The transcription factor FOXM1 is upregulated and overexpressed in aggressive, therapy-resistant forms of hormone receptor-positive and triple negative breast cancers, and is associated with less good patient survival. FOXM1 signaling is also a key driver in many other cancers. Here, we identify a n...

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Détails bibliographiques
Publié dans:NPJ Breast Cancer
Auteurs principaux: Ziegler, Yvonne, Laws, Mary J., Sanabria Guillen, Valeria, Kim, Sung Hoon, Dey, Parama, Smith, Brandi P., Gong, Ping, Bindman, Noah, Zhao, Yuechao, Carlson, Kathryn, Yasuda, Mayuri A., Singh, Divya, Li, Zhong, El-Ashry, Dorraya, Madak-Erdogan, Zeynep, Katzenellenbogen, John A., Katzenellenbogen, Benita S.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6884575/
https://ncbi.nlm.nih.gov/pubmed/31815181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41523-019-0141-7
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