Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex

Cortical collapse factors affect microtubule (MT) dynamics at the plasma membrane. They play important roles in neurons, as suggested by inhibition of axon growth and regeneration through the ARF activator Efa6 in C. elegans, and by neurodevelopmental disorders linked to the mammalian kinesin Kif21A...

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Vydáno v:eLife
Hlavní autoři: Qu, Yue, Hahn, Ines, Lees, Meredith, Parkin, Jill, Voelzmann, André, Dorey, Karel, Rathbone, Alex, Friel, Claire T, Allan, Victoria J, Okenve-Ramos, Pilar, Sanchez-Soriano, Natalia, Prokop, Andreas
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2019
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6884004/
https://ncbi.nlm.nih.gov/pubmed/31718774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50319
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