Intrinsic elasticity of nucleosomes is encoded by histone variants and calibrated by their binding partners

Histone variants fine-tune transcription, replication, DNA damage repair, and faithful chromosome segregation. Whether and how nucleosome variants encode unique mechanical properties to their cognate chromatin structures remains elusive. Here, using in silico and in vitro nanoindentation methods, ex...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Melters, Daniël P., Pitman, Mary, Rakshit, Tatini, Dimitriadis, Emilios K., Bui, Minh, Papoian, Garegin A., Dalal, Yamini
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2019
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6883791/
https://ncbi.nlm.nih.gov/pubmed/31712435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1911880116
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