Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences

Infection of animal cells by numerous viruses is detected and countered by a variety of means, including recognition of nonself nucleic acids. The zinc finger antiviral protein (ZAP) depletes cytoplasmic RNA that is recognized as foreign in mammalian cells by virtue of its elevated CG dinucleotide c...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Meagher, Jennifer L., Takata, Matthew, Gonçalves-Carneiro, Daniel, Keane, Sarah C., Rebendenne, Antoine, Ong, Heley, Orr, Victoria K., MacDonald, Margaret R., Stuckey, Jeanne A., Bieniasz, Paul D., Smith, Janet L.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6883784/
https://ncbi.nlm.nih.gov/pubmed/31719195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913232116
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