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CG-dinucleotide suppression enables antiviral defense targeting non-self RNA

Vertebrate genomes exhibit marked CG-suppression, that is lower than expected numbers of 5′-CG-3′ dinucleotides(1). This feature is likely due to C-to-T mutations that have accumulated over hundreds of millions of years, driven by CG-specific DNA methyl transferases and spontaneous methyl-cytosine d...

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Pubblicato in:Nature
Autori principali: Takata, Matthew A., Gonçalves-Carneiro, Daniel, Zang, Trinity, Soll, Steven J., York, Ashley, Blanco-Melo, Daniel, Bieniasz, Paul D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6592701/
https://ncbi.nlm.nih.gov/pubmed/28953888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature24039
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