Murine sepsis phenotypes and differential treatment effects in a randomized trial of prompt antibiotics and fluids

BACKGROUND: Clinical and biologic phenotypes of sepsis are proposed in human studies, yet it is unknown whether prognostic or drug response phenotypes are present in animal models of sepsis. Using a biotelemetry-enhanced, murine cecal ligation and puncture (CLP) model, we determined phenotypes of po...

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Bibliografiske detaljer
Udgivet i:Crit Care
Main Authors: Seymour, Christopher W., Kerti, Samantha J., Lewis, Anthony J., Kennedy, Jason, Brant, Emily, Griepentrog, John E., Zhang, Xianghong, Angus, Derek C., Chang, Chung-Chou H., Rosengart, Matthew R.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6883631/
https://ncbi.nlm.nih.gov/pubmed/31779663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13054-019-2655-7
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