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Use of biotelemetry to define physiology-based deterioration thresholds in a murine cecal ligation and puncture model of sepsis

OBJECTIVE: Murine models of critical illness are commonly used to test new therapeutic interventions. However, these interventions are often administered at fixed time intervals after the insult, perhaps ignoring the inherent variability in magnitude and temporality of the host response. We propose...

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Detalhes bibliográficos
Publicado no:Crit Care Med
Main Authors: Lewis, Anthony J., Yuan, Du, Zhang, Xianghong, Angus, Derek C., Rosengart, Matthew R., Seymour, Christopher W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868666/
https://ncbi.nlm.nih.gov/pubmed/26862708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000001615
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