Targeting histone deacetylase 3 (HDAC3) in the bone marrow microenvironment inhibits multiple myeloma proliferation by modulating exosomes and IL-6 trans-signaling

Multiple myeloma (MM) is an incurable cancer that derives pro-survival/proliferative signals from the bone marrow (BM) niche. Novel agents targeting not only cancer cells, but also the BM-niche have shown the greatest activity in MM. Histone deacetylases (HDACs) are therapeutic targets in MM and we...

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Publicado no:Leukemia
Main Authors: Ho, Matthew, Chen, Tianzeng, Liu, Jiye, Dowling, Paul, Hideshima, Teru, Zhang, Li, Morelli, Eugenio, Camci-Unal, Gulden, Wu, Xinchen, Tai, Yu-Tzu, Wen, Kenneth, Samur, Mehmet, Schlossman, Robert L., Mazitschek, Ralph, Kavanagh, Emma L., Lindsay, Sinéad, Harada, Takeshi, McCann, Amanda, Anderson, Kenneth C., O’Gorman, Peter, Bianchi, Giada
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6883144/
https://ncbi.nlm.nih.gov/pubmed/31142847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-019-0493-x
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