PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death

5-Fluorouracil (5-FU) is known as a first-line chemotherapeutic agent against colorectal cancer (CRC), but drug resistance occurs frequently and significantly limits its clinical success. Our previous study showed that the protocadherin 17 (PCDH17) gene was frequently methylated and functioned as a...

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Publicado no:Signal Transduct Target Ther
Main Authors: Liu, Shuiping, Lin, Haoming, Wang, Da, Li, Qiang, Luo, Hong, Li, Guoxiong, Chen, Xiaohui, Li, Yongqiang, Chen, Peng, Zhai, Bingtao, Wang, Wengang, Zhang, Ruonan, Chen, Bi, Zhang, Mingming, Han, Xuemeng, Li, Qiujie, Chen, Liuxi, Liu, Ying, Chen, Xiaying, Li, Guohua, Xiang, Yu, Duan, Ting, Feng, Jiao, Lou, Jianshu, Huang, Xingxing, Zhang, Qin, Pan, Ting, Yan, Lili, Jin, Ting, Zhang, Wenzheng, Zhuo, Lvjia, Sun, Yitian, Xie, Tian, Sui, Xinbing
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6882894/
https://ncbi.nlm.nih.gov/pubmed/31815010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-019-0087-0
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