β-Elemene Reverses the Resistance of p53-Deficient Colorectal Cancer Cells to 5-Fluorouracil by Inducing Pro-death Autophagy and Cyclin D3-Dependent Cycle Arrest

OBJECTIVE: Colorectal cancer is a malignant tumor of the digestive system with high morbidity and mortality. 5-fluorouracil remains a widely used chemotherapeutic drug in the treatment of advanced colorectal cancer, but chemotherapy drugs are prone to develop drug resistance, p53 deletion or mutatio...

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Detalhes bibliográficos
Publicado no:Front Bioeng Biotechnol
Main Authors: Zhang, Ruonan, Pan, Ting, Xiang, Yu, Zhang, Mingming, Feng, Jiao, Liu, Shuiping, Duan, Ting, Chen, Peng, Zhai, Bingtao, Chen, Xiaying, Wang, Wengang, Chen, Bi, Han, Xuemeng, Chen, Liuxi, Yan, Lili, Jin, Ting, Liu, Ying, Li, Guohua, Huang, Xingxing, Zhang, Wenzheng, Sun, Yitian, Li, Qiujie, Zhang, Qin, Zhuo, Lvjia, Xie, Tian, Wu, Qibiao, Sui, Xinbing
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Bioengineering and Biotechnology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7225311/
https://ncbi.nlm.nih.gov/pubmed/32457882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2020.00378
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