Barley-ß-glucans reduce systemic inflammation, renal injury and aortic calcification through ADAM17 and neutral-sphingomyelinase2 inhibition

In chronic kidney disease (CKD), hyperphosphatemia-induced inflammation aggravates vascular calcification (VC) by increasing vascular smooth muscle cell (VSMC) osteogenic differentiation, ADAM17-induced renal and vascular injury, and TNFα-induction of neutral-sphingomyelinase2 (nSMase2) to release p...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Arcidiacono, Maria Vittoria, Carrillo-López, Natalia, Panizo, Sara, Castro-Grattoni, Anabel L., Valcheva, Petya, Ulloa, Catalina, Rodríguez-Carrio, Javier, Cardús, Anna, Quirós-Caso, Covadonga, Martínez-Arias, Laura, Martínez-Salgado, Carlos, Motilva, María José, Rodriguez-Suarez, Carmen, Cannata-Andía, Jorge B., Dusso, Adriana S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6882851/
https://ncbi.nlm.nih.gov/pubmed/31780737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54306-8
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