Carprofen-induced depletion of proton motive force reverses TetK-mediated doxycycline resistance in methicillin-resistant Staphylococcus pseudintermedius

We previously showed that doxycycline (DOX) and carprofen (CPF), a veterinary non-steroidal anti-inflammatory drug, have synergistic antimicrobial activity against methicillin-resistant Staphylococcus pseudintermedius (MRSP) carrying the tetracycline resistance determinant TetK. To elucidate the mol...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Magnowska, Zofia, Jana, Bimal, Brochmann, Rikke Prejh, Hesketh, Andrew, Lametsch, Rene, De Gobba, Cristian, Guardabassi, Luca
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6882848/
https://ncbi.nlm.nih.gov/pubmed/31780689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54091-4
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