Epithelial tumor suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinoma

Gene function in cancer is often cell type-specific. The epithelial cell-specific transcription factor ELF3 is a documented tumor suppressor in many epithelial tumors yet displays oncogenic properties in others. Here, we show that ELF3 is an oncogene in the adenocarcinoma subtype of lung cancer (LUA...

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Udgivet i:Nat Commun
Main Authors: Enfield, Katey S. S., Marshall, Erin A., Anderson, Christine, Ng, Kevin W., Rahmati, Sara, Xu, Zhaolin, Fuller, Megan, Milne, Katy, Lu, Daniel, Shi, Rocky, Rowbotham, David A., Becker-Santos, Daiana D., Johnson, Fraser D., English, John C., MacAulay, Calum E., Lam, Stephen, Lockwood, William W., Chari, Raj, Karsan, Aly, Jurisica, Igor, Lam, Wan L.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6882813/
https://ncbi.nlm.nih.gov/pubmed/31780666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13295-y
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