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One-Carbon Metabolism Regulates Embryonic Stem Cell Fate Through Epigenetic DNA and Histone Modifications: Implications for Transgenerational Metabolic Disorders in Adults

Human (h) and mouse (m) embryonic stem (ES) cells need specific amino acids to proliferate. mES cells require threonine (Thr) metabolism for epigenetic histone modifications. Thr is converted to glycine and acetyl CoA, and the glycine is metabolized specifically to regulate trimethylation of lysine...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Van Winkle, Lon J., Ryznar, Rebecca
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6882271/
https://ncbi.nlm.nih.gov/pubmed/31824950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2019.00300
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