Identification of Two DNMT3A Mutations Compromising Protein Stability and Methylation Capacity in Acute Myeloid Leukemia

Somatic mutations of DNMT3A occur in about 20% of acute myeloid leukemia (AML) patients. They mostly consist in heterozygous missense mutations targeting a hotspot site at R882 codon, which exhibit a dominant negative effect and are associated with high myeloblast count, advanced age, and poor progn...

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Bibliografske podrobnosti
izdano v:J Oncol
Main Authors: Bruno, Samantha, Bochicchio, Maria Teresa, Franchini, Eugenia, Padella, Antonella, Marconi, Giovanni, Ghelli Luserna di Rorà, Andrea, Venturi, Claudia, Raffini, Maddalena, Prisinzano, Giovanna, Ferrari, Anna, Bandini, Lorenza, Robustelli, Valentina, Pazzaglia, Martina, Fontana, Maria Chiara, Sartor, Chiara, Abbenante, Maria Chiara, Papayannidis, Cristina, Soverini, Simona, Ottaviani, Emanuela, Simonetti, Giorgia, Martinelli, Giovanni
Format: Artigo
Jezik:Inglês
Izdano: Hindawi 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6881567/
https://ncbi.nlm.nih.gov/pubmed/31827512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/5985923
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