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Direct visualization of human myosin II force generation using DNA origami-based thick filaments

The sarcomere, the minimal mechanical unit of muscle, is composed of myosins, which self-assemble into thick filaments that interact with actin-based thin filaments in a highly-structured lattice. This complex imposes a geometric restriction on myosin in force generation. However, how single myosins...

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Detalhes bibliográficos
Publicado no:Commun Biol
Main Authors: Fujita, Keisuke, Ohmachi, Masashi, Ikezaki, Keigo, Yanagida, Toshio, Iwaki, Mitsuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6881340/
https://ncbi.nlm.nih.gov/pubmed/31799438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0683-0
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