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Allosteric modulation of nucleoporin assemblies by intrinsically disordered regions

Intrinsically disordered regions (IDRs) of proteins are implicated in key macromolecular interactions. However, the molecular forces underlying IDR function within multicomponent assemblies remain elusive. By combining thermodynamic and structural data, we have discovered an allostery-based mechanis...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Blus, Bartlomiej Jan, Koh, Junseock, Krolak, Aleksandra, Seo, Hyuk-Soo, Coutavas, Elias, Blobel, Günter
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6881172/
https://ncbi.nlm.nih.gov/pubmed/31807700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax1836
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