Massive clonal expansion of medulloblastoma-specific T cells during adoptive cellular therapy

In both human and murine systems, we have developed an adoptive cellular therapy platform against medulloblastoma and glioblastoma that uses dendritic cells pulsed with a tumor RNA transcriptome to expand polyclonal tumor-reactive T cells against a plurality of antigens within heterogeneous brain tu...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Flores, C., Wildes, T., Dean, B. DiVita, Moore, G., Drake, J., Abraham, R., Gil, J., Yegorov, O., Yang, C., Dean, J., Moneypenny, C., Shin, D., Pham, C., Krauser, J., King, J., Grant, G., Driscoll, T., Kurtzberg, J., McLendon, R., Gururangan, S., Mitchell, D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6881165/
https://ncbi.nlm.nih.gov/pubmed/31807694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav9879
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