PDCT-12. TRACKING T-CELL IMMUNE RECONSTITUTION AFTER ADOPTIVE CELLULAR THERAPY TARGETING RECURRENT MEDULLOBLASTOMA AND PNETS USING DEEP T-CELL RECEPTOR (TCR) REPERTOIRE SEQUENCING

BACKGROUND: Adoptive cellular therapy (ACT) using transfer of tumor-specific lymphocytes has demonstrated significant clinical activity in different cancers. T-cells represent a crucial component of the adaptive immune system and are able to mediate antitumor immunity. We have employed deep TCR repe...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Yegorov, Oleg, Yegorova, Yanina, Dechkovskaia, Anjelika, Huang, Jianping, Gururangan, Sridharan, Mitchell, Duane
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692728/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.755
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