Gpr63 is a modifier of microcephaly in Ttc21b mouse mutants

The primary cilium is a signaling center critical for proper embryonic development. Previous studies have demonstrated that mice lacking Ttc21b have impaired retrograde trafficking within the cilium and multiple organogenesis phenotypes, including microcephaly. Interestingly, the severity of the mic...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Genet
Prif Awduron: Snedeker, John, Gibbons, William J., Paulding, David F., Abdelhamed, Zakia, Prows, Daniel R., Stottmann, Rolf W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2019
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6881074/
https://ncbi.nlm.nih.gov/pubmed/31730647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008467
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