Electrostatic interactions at the five-fold axis alter heparin-binding phenotype and drive enterovirus A71 virulence in mice

Enterovirus A71 (EV-A71) causes hand, foot and mouth disease epidemics with neurological complications and fatalities. However, the neuropathogenesis of EV-A71 remains poorly understood. In mice, adaptation and virulence determinants have been mapped to mutations at VP2-149, VP1-145 and VP1-244. We...

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Vydáno v:PLoS Pathog
Hlavní autoři: Tee, Han Kang, Tan, Chee Wah, Yogarajah, Thinesshwary, Lee, Michelle Hui Pheng, Chai, Hann Juang, Hanapi, Nur Aziah, Yusof, Siti R., Ong, Kien Chai, Lee, Vannajan Sanghiran, Sam, I-Ching, Chan, Yoke Fun
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6881073/
https://ncbi.nlm.nih.gov/pubmed/31730673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007863
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