First hyperpolarized [2-(13)C]pyruvate MR studies of human brain metabolism

We developed methods for the preparation of hyperpolarized (HP) sterile [2-(13)C]pyruvate to test its feasibility in first-ever human NMR studies following FDA-IND & IRB approval. Spectral results using this MR stable-isotope imaging approach demonstrated the feasibility of investigating human c...

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Bibliografiske detaljer
Udgivet i:J Magn Reson
Main Authors: Chung, Brian T., Chen, Hsin-Yu, Gordon, Jeremy, Mammoli, Daniele, Sriram, Renuka, Autry, Adam W., Le Page, Lydia M., Chaumeil, Myriam, Shin, Peter, Slater, James, Tan, Chou T., Suszczynski, Chris, Chang, Susan, Li, Yan, Bok, Robert A., Ronen, Sabrina M., Larson, Peder E.Z., Kurhanewicz, John, Vigneron, Daniel B.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880930/
https://ncbi.nlm.nih.gov/pubmed/31648132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmr.2019.106617
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