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Macromolecular Synthesis Shutoff Resistance by Myeloid Cells Is Critical to IRF7-Dependent Systemic Interferon Alpha/Beta Induction after Alphavirus Infection

Alphavirus infection of fibroblastic cell types in vitro inhibits host cell translation and transcription, leading to suppression of interferon alpha/beta (IFN-α/β) production. However, the effect of infection upon myeloid cells, which are often the first cells encountered by alphaviruses in vivo, i...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Bhalla, Nishank, Gardner, Christina L., Downs, Sierra N., Dunn, Matthew, Sun, Chengqun, Klimstra, William B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880179/
https://ncbi.nlm.nih.gov/pubmed/31578290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00872-19
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