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Measuring Transcription at a Single Gene Copy Reveals Hidden Drivers of Bacterial Individuality

Single-cell measurements of mRNA copy-number inform our understanding of stochastic gene expression [1-3], but these measurements coarse-grain over the individual copies of the gene, where transcription and its regulation stochastically take plasce [4, 5]. Here we combine single-molecule quantificat...

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Publicat a:Nat Microbiol
Autors principals: Wang, Mengyu, Zhang, Jing, Xu, Heng, Golding, Ido
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879826/
https://ncbi.nlm.nih.gov/pubmed/31527794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-019-0553-z
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