Integration of Multiple Epigenomic Marks Improves Prediction of Variant Impact in Saturation Mutagenesis Reporter Assay

Integrative analysis of high-throughput reporter assays, machine learning, and profiles of epigenomic chromatin state in a broad array of cells and tissues has the potential to significantly improve our understanding of non-coding regulatory element function and its contribution to human disease. He...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Hum Mutat
Prif Awduron: Shigaki, Dustin, Adato, Orit, Adhikar, Aashish N., Dong, Shengcheng, Hawkins-Hooker, Alex, Inoue, Fumitaka, Juven-Gershon, Tamar, Kenlay, Henry, Martin, Beth, Patra, Ayoti, Penzar, Dmitry P., Schubach, Max, Xiong, Chenling, Yan, Zhongxia, Boyle, Alan P., Kreimer, Anat, Kulakovskiy, Ivan V., Reid, John, Unger, Ron, Yosef, Nir, Shendure, Jay, Ahituv, Nadav, Kircher, Martin, Beer, Michael A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879779/
https://ncbi.nlm.nih.gov/pubmed/31106481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.23797
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