Invariant patterns of clonal succession determine specific clinical features of myelodysplastic syndromes

Myelodysplastic syndromes (MDS) arise in older adults through stepwise acquisitions of multiple somatic mutations. Here, analyzing 1809 MDS patients, we infer clonal architecture by using a stringent, the single-cell sequencing validated PyClone bioanalytic pipeline, and assess the position of the m...

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Publicado en:Nat Commun
Main Authors: Nagata, Yasunobu, Makishima, Hideki, Kerr, Cassandra M., Przychodzen, Bartlomiej P., Aly, Mai, Goyal, Abhinav, Awada, Hassan, Asad, Mohammad Fahad, Kuzmanovic, Teodora, Suzuki, Hiromichi, Yoshizato, Tetsuichi, Yoshida, Kenichi, Chiba, Kenichi, Tanaka, Hiroko, Shiraishi, Yuichi, Miyano, Satoru, Mukherjee, Sudipto, LaFramboise, Thomas, Nazha, Aziz, Sekeres, Mikkael A., Radivoyevitch, Tomas, Haferlach, Torsten, Ogawa, Seishi, Maciejewski, Jaroslaw P.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879617/
https://ncbi.nlm.nih.gov/pubmed/31772163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13001-y
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