Invariant patterns of clonal succession determine specific clinical features of myelodysplastic syndromes

Myelodysplastic syndromes (MDS) arise in older adults through stepwise acquisitions of multiple somatic mutations. Here, analyzing 1809 MDS patients, we infer clonal architecture by using a stringent, the single-cell sequencing validated PyClone bioanalytic pipeline, and assess the position of the m...

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Vydáno v:Nat Commun
Hlavní autoři: Nagata, Yasunobu, Makishima, Hideki, Kerr, Cassandra M., Przychodzen, Bartlomiej P., Aly, Mai, Goyal, Abhinav, Awada, Hassan, Asad, Mohammad Fahad, Kuzmanovic, Teodora, Suzuki, Hiromichi, Yoshizato, Tetsuichi, Yoshida, Kenichi, Chiba, Kenichi, Tanaka, Hiroko, Shiraishi, Yuichi, Miyano, Satoru, Mukherjee, Sudipto, LaFramboise, Thomas, Nazha, Aziz, Sekeres, Mikkael A., Radivoyevitch, Tomas, Haferlach, Torsten, Ogawa, Seishi, Maciejewski, Jaroslaw P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879617/
https://ncbi.nlm.nih.gov/pubmed/31772163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13001-y
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