Interaction of ArmZ with the DNA-Binding Domain of MexZ Induces Expression of mexXY Multidrug Efflux Pump Genes and Antimicrobial Resistance in Pseudomonas aeruginosa

Multidrug efflux pumps play an important role in antibiotic resistance in bacteria. In Pseudomonas aeruginosa, the MexXY pump provides intrinsic resistance to many antimicrobials, including aminoglycosides. The expression of the mexXY operon is negatively regulated by the MexZ repressor. This repres...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Kawalek, Adam, Modrzejewska, Magdalena, Zieniuk, Bartlomiej, Bartosik, Aneta Agnieszka, Jagura-Burdzy, Grazyna
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879243/
https://ncbi.nlm.nih.gov/pubmed/31527038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01199-19
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