Gastric acid inhibitor aggravates indomethacin-induced small intestinal injury via reducing Lactobacillus johnsonii

Proton pump inhibitors (PPIs) alter the composition of the intestinal microbiome, exacerbating indomethacin (IND)-induced small intestinal damage. Vonoprazan fumarate inhibits gastric acid secretion using a different mechanism from PPIs. We investigated the effects of both drugs on the intestinal mi...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Nadatani, Yuji, Watanabe, Toshio, Suda, Wataru, Nakata, Akinobu, Matsumoto, Yuji, Kosaka, Satoshi, Higashimori, Akira, Otani, Koji, Hosomi, Shuhei, Tanaka, Fumio, Nagami, Yasuaki, Kamata, Noriko, Taira, Koichi, Yamagami, Hirokazu, Tanigawa, Tetsuya, Hattori, Masahira, Fujiwara, Yasuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6877529/
https://ncbi.nlm.nih.gov/pubmed/31767915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53559-7
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