Hedgehog signaling promotes tumor-associated macrophage polarization to suppress intratumoral CD8(+) T cell recruitment

Tumor-associated macrophages (TAMs) usually display an antiinflammatory M2-like phenotype to facilitate tumor growth. However, what drives M2 polarization of TAMs and how TAMs suppress antitumor immunity within the tumor microenvironment (TME) remain largely undefined. Using several murine tumor mod...

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Xehetasun bibliografikoak
Argitaratua izan da:J Clin Invest
Egile Nagusiak: Petty, Amy J., Li, Ang, Wang, Xinyi, Dai, Rui, Heyman, Benjamin, Hsu, David, Huang, Xiaopei, Yang, Yiping
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2019
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6877305/
https://ncbi.nlm.nih.gov/pubmed/31638600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI128644
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