Macrophage IL-10 blocks CD8(+) T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells

Blockade of colony-stimulating factor-1 (CSF-1) limits macrophage infiltration and improves response of mammary carcinomas to chemotherapy. Herein we identify interleukin (IL)-10 expression by macrophages as the critical mediator of this phenotype. Infiltrating macrophages were the primary source of...

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Publicado no:Cancer Cell
Main Authors: Ruffell, Brian, Chang-Strachan, Debbie, Chan, Vivien, Rosenbusch, Alexander, Ho, Christine M.T., Pryer, Nancy, Daniel, Dylan, Hwang, E. Shelley, Rugo, Hope S., Coussens, Lisa M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254570/
https://ncbi.nlm.nih.gov/pubmed/25446896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2014.09.006
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