The S phase checkpoint promotes the Smc5/6 complex dependent SUMOylation of Pol2, the catalytic subunit of DNA polymerase ε

Replication fork stalling and accumulation of single-stranded DNA trigger the S phase checkpoint, a signalling cascade that, in budding yeast, leads to the activation of the Rad53 kinase. Rad53 is essential in maintaining cell viability, but its targets of regulation are still partially unknown. Her...

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Bibliographic Details
Published in:PLoS Genet
Main Authors: Winczura, Alicja, Appanah, Rowin, Tatham, Michael H., Hay, Ronald T., De Piccoli, Giacomo
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6876773/
https://ncbi.nlm.nih.gov/pubmed/31765407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008427
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