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A Simple Assay to Evaluate the Function of Human Connexin Hemichannels Expressed in Escherichia Coli that Can be Used for Drug Discovery and Mutants’ Analysis: Functional Assay of Human Connexin Hemichannels

Abnormally increased activity of connexin hemichannels contributes to cell damage in many disorders, including deafness, stroke and cardiac infarct, and therefore, hemichannels constitute a potentially important therapeutic target. Unfortunately, the available hemichannel inhibitors are not specific...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Curr Protoc Pharmacol
Prif Awduron: Fiori, Mariana C., Cuello, Luis G., Altenberg, Guillermo A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6876698/
https://ncbi.nlm.nih.gov/pubmed/31756040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpph.68
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