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Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance

Most cancers are resistant to anti-PD-1/PD-L1 and chemotherapy. Herein we identify PDLIM2 as a tumor suppressor particularly important for lung cancer therapeutic responses. While PDLIM2 is epigenetically repressed in human lung cancer, associating with therapeutic resistance and poor prognosis, its...

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Publicat a:Nat Commun
Autors principals: Sun, Fan, Li, Liwen, Yan, Pengrong, Zhou, Jingjiao, Shapiro, Steven D., Xiao, Gutian, Qu, Zhaoxia
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6876573/
https://ncbi.nlm.nih.gov/pubmed/31757943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13331-x
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