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Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance
Most cancers are resistant to anti-PD-1/PD-L1 and chemotherapy. Herein we identify PDLIM2 as a tumor suppressor particularly important for lung cancer therapeutic responses. While PDLIM2 is epigenetically repressed in human lung cancer, associating with therapeutic resistance and poor prognosis, its...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6876573/ https://ncbi.nlm.nih.gov/pubmed/31757943 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13331-x |
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