Gene expression of ASNS, LGMN and CTSB is elevated in a subgroup of childhood BCP-ALL with PAX5 deletion

Resistance to L-asparaginase (L-asp) is a major contributor to poor treatment outcomes of several subtypes of childhood B cell precursor acute lymphoblastic leukemia (BCP-ALL). Asparagine synthetase (ASNS), legumain (LGMN) and cathepsin B (CTSB) serve a key role in L-asp resistance. The association...

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Detalles Bibliográficos
Publicado en:Oncol Lett
Main Authors: Wrona, Ewa, Jakubowska, Justyna, Pawlik, Bartłomiej, Pastorczak, Agata, Madzio, Joanna, Lejman, Monika, Sędek, Łukasz, Kowalczyk, Jerzy, Szczepański, Tomasz, Młynarski, Wojciech
Formato: Artigo
Idioma:Inglês
Publicado: D.A. Spandidos 2019
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6876287/
https://ncbi.nlm.nih.gov/pubmed/31807194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2019.11046
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