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Immunological ignorance is an enabling feature of the oligo-clonal T cell response to melanoma neoantigens

The impact of intratumoral heterogeneity (ITH) and the resultant neoantigen landscape on T cell immunity are poorly understood. ITH is a widely recognized feature of solid tumors and poses distinct challenges related to the development of effective therapeutic strategies, including cancer neoantigen...

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Podrobná bibliografie
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Linette, Gerald P., Becker-Hapak, Michelle, Skidmore, Zachary L., Baroja, Miren Lorea, Xu, Chong, Hundal, Jasreet, Spencer, David H., Fu, Weixuan, Cummins, Casey, Robnett, Maya, Kaabinejadian, Saghar, Hildebrand, William H., Magrini, Vincent, Demeter, Ryan, Krupnick, Alexander S., Griffith, Obi L., Griffith, Malachi, Mardis, Elaine R., Carreno, Beatriz M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6876217/
https://ncbi.nlm.nih.gov/pubmed/31685621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906026116
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