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Immunological ignorance is an enabling feature of the oligo-clonal T cell response to melanoma neoantigens

The impact of intratumoral heterogeneity (ITH) and the resultant neoantigen landscape on T cell immunity are poorly understood. ITH is a widely recognized feature of solid tumors and poses distinct challenges related to the development of effective therapeutic strategies, including cancer neoantigen...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Proc Natl Acad Sci U S A
Κύριοι συγγραφείς: Linette, Gerald P., Becker-Hapak, Michelle, Skidmore, Zachary L., Baroja, Miren Lorea, Xu, Chong, Hundal, Jasreet, Spencer, David H., Fu, Weixuan, Cummins, Casey, Robnett, Maya, Kaabinejadian, Saghar, Hildebrand, William H., Magrini, Vincent, Demeter, Ryan, Krupnick, Alexander S., Griffith, Obi L., Griffith, Malachi, Mardis, Elaine R., Carreno, Beatriz M.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: National Academy of Sciences 2019
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6876217/
https://ncbi.nlm.nih.gov/pubmed/31685621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906026116
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