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Pat1 activates late steps in mRNA decay by multiple mechanisms

Pat1 is a hub for mRNA metabolism, acting in pre-mRNA splicing, translation repression, and mRNA decay. A critical step in all 5′-3′ mRNA decay pathways is removal of the 5′ cap structure, which precedes and permits digestion of the RNA body by conserved exonucleases. During bulk 5′-3′ decay, the Pa...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Lobel, Joseph H., Tibble, Ryan W., Gross, John D.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6876151/
https://ncbi.nlm.nih.gov/pubmed/31690658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905455116
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