Depot-medroxyprogesterone acetate reduces genital cell-cell adhesion molecule expression and increases genital herpes simplex virus type 2 infection susceptibility in a dose-dependent fashion

OBJECTIVE: Analyzing ectocervical biopsy tissue from women before and after they initiated use of depot-medroxyprogesterone acetate (DMPA), we previously reported this progestin reduces levels of the cell-cell adhesion molecule (CCAM) desmoglein-1 and increases genital mucosal permeability. We likew...

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Bibliographic Details
Published in:Contraception
Main Authors: Calla, Nirk E. Quispe, Miguel, Rodolfo D. Vicetti, Aceves, Kristen M., Torres, Angelo, Cherpes, Thomas L.
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6875619/
https://ncbi.nlm.nih.gov/pubmed/31302121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.contraception.2019.07.003
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