Berberine Modulates LPA Function to Inhibit the Proliferation and Inflammation of FLS-RA via p38/ERK MAPK Pathway Mediated by LPA(1)

OBJECTIVE: This study aimed to investigate whether berberine exerted anti-inflammatory and antiproliferative effects on the fibroblast-like synoviocytes of rheumatoid arthritis (FLS-RA) through regulating the lysophosphatidic acid (LPA) function. METHODS: Firstly, the expression levels of LPA and ly...

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Pubblicato in:Evid Based Complement Alternat Med
Autori principali: Wang, Hui, Tu, Shenghao, Yang, Sisi, Shen, Pan, Huang, Yao, Ba, Xin, Lin, Weiji, Huang, Ying, Wang, Yu, Qin, Kai, Chen, Zhe
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6875284/
https://ncbi.nlm.nih.gov/pubmed/31781264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/2580207
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