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Berberine Modulates LPA Function to Inhibit the Proliferation and Inflammation of FLS-RA via p38/ERK MAPK Pathway Mediated by LPA1

Objective. This study aimed to investigate whether berberine exerted anti-inflammatory and antiproliferative effects on the fibroblast-like synoviocytes of rheumatoid arthritis (FLS-RA) through regulating the lysophosphatidic acid (LPA) function. Methods. Firstly, the expression levels of LPA and ly...

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Detalhes bibliográficos
Main Authors: Hui Wang, Shenghao Tu, Sisi Yang, Pan Shen, Yao Huang, Xin Ba, Weiji Lin, Ying Huang, Yu Wang, Kai Qin, Zhe Chen
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Limited 2019-01-01
Colecção:Evidence-Based Complementary and Alternative Medicine
Acesso em linha:http://dx.doi.org/10.1155/2019/2580207
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