Steady-State Plasma Concentrations of Polyethylene Glycol (PEG) are Reached in Children and Adults During Once-Weekly Prophylactic Treatment with Nonacog Beta Pegol (N9-GP)

BACKGROUND: Nonacog beta pegol (N9-GP, Refixia(®), Rebinyn(®)) is a human recombinant coagulation factor IX (rFIX) conjugated to a 40-kDa polyethylene glycol (PEG) moiety. PEGylation significantly prolongs the circulation half-life compared with conventional FIX replacement treatments, resulting in...

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Dettagli Bibliografici
Pubblicato in:BioDrugs
Autori principali: Sternebring, Ola, Gabel-Jensen, Charlotte, Jacobsen, Helene, Benie, Andrew James, Bjørnsdottir, Inga
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer International Publishing 2019
Soggetti:
Original Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6875145/
https://ncbi.nlm.nih.gov/pubmed/31549312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40259-019-00380-3
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