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Deamidation disrupts native and transient contacts to weaken the interaction between UBC13 and RING-finger E3 ligases
The deamidase OspI from enteric bacteria Shigella flexneri deamidates a glutamine residue in the host ubiquitin-conjugating enzyme UBC13 and converts it to glutamate (Q100E). Consequently, its polyubiquitination activity in complex with the RING-finger ubiquitin ligase TRAF6 and the downstream NF-κB...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6874479/ https://ncbi.nlm.nih.gov/pubmed/31638574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.49223 |
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