Oncogenic USP22 supports gastric cancer growth and metastasis by activating c-Myc/NAMPT/SIRT1-dependent FOXO1 and YAP signaling

In this study, we investigated the role of ubiquitin-specific protease 22 (USP22) in the growth and progression of gastric cancer (GC). USP22 mRNA and protein levels were significantly higher in GC tissue samples and GC cell lines than in adjacent noncancerous tissue samples and a normal gastric muc...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Liu, Hongxia, Liu, Ningning, Zhao, Yali, Zhu, Xiaoshan, Wang, Changsong, Liu, Qinqin, Gao, Chunfang, Zhao, Xusheng, Li, Juntang
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874452/
https://ncbi.nlm.nih.gov/pubmed/31689236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102410
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