Organoruthenium(II) Complexes Bearing an Aromatase Inhibitor: Synthesis, Characterization, in Vitro Biological Activity and in Vivo Toxicity in Zebrafish Embryos

Third-generation aromatase inhibitors such as anastrozole (ATZ) and letrozole (LTZ) are widely used to treat estrogen receptor-positive ER+ breast cancers in postmenopausal women. Investigating their ability to coordinate metals could lead to the emergence of a new category of anticancer drug candid...

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Udgivet i:Organometallics
Main Authors: Golbaghi, Golara, Haghdoost, Mohammad Mehdi, Yancu, Debbie, Santos, Yossef López de los, Doucet, Nicolas, Patten, Shunmoogum A., Sanderson, J. Thomas, Castonguay, Annie
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874409/
https://ncbi.nlm.nih.gov/pubmed/31762529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.organomet.8b00897
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