Robust Iterative Stimulation with Self-Antigens Overcomes CD8(+) T Cell Tolerance to Self- and Tumor Antigens

The immune system adapts to constitutive antigens to preserve self-tolerance, which is a major barrier for anti-tumor immunity. Antigen-specific reversal of tolerance constitutes a major goal to spur therapeutic applications. Here, we show that robust, iterative, systemic stimulation targeting tissu...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Nelson, Christine E., Thompson, Emily A., Quarnstrom, Clare F., Fraser, Kathryn A., Seelig, Davis M., Bhela, Siddheshvar, Burbach, Brandon J., Masopust, David, Vezys, Vaiva
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874401/
https://ncbi.nlm.nih.gov/pubmed/31533033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.08.038
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